Biology Online Module Handbook

BL4215 Bacterial Virulence Factors

(BL4215 online module handbook version 15)

cover image

image: Fibronectin-mediated Streptococcus pyogenes invasion of a host cell.

In order to establish an infection in a host, pathogenic bacteria rely on mechanisms to adhere to host tissue, gain entry into cells, escape the host's immune response and spread and survive within or on the host. These processes are mediated by bacterial virulence factors, i.e. proteins and other bacterial products that utilise and subvert diverse host cellular processes for the benefit of the pathogen. In this module students will explore how structural biology has led to significant breakthroughs in understanding the molecular bases of some important bacterial infections.*

Credits: 15*

Semester: 1

Module Organiser
Dr Uli Schwarz-Linek
us6@st-andrews.ac.uk
01334 467188
Pre-requisite Modules:
BEFORE TAKING THIS MODULE YOU SHOULD PASS BL3301*
Anti-requisite Modules:
None*
Post-requisite Modules:
*
Additional Module Information:
Please check MMS regularly for additional module information


Biology Teaching Office:
Room 1.17, Biomolecular Sciences Building, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST

Email: bioteach@st-andrews.ac.uk      Tel: 01334  463602

BL4215: Timetable

Legend (not all modules have every event type):
lecture
tutorial
workshop
practical
other

Semester 1: Week 1

DATE & TIMEVENUESTAFFEVENT
Tuesday
19-09-2017
16:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L1: Module introduction
2017-8_BL4215_L1
Wednesday
20-09-2017
16:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L2: Bacterial secretion systems I
2017-8_BL4215_L2

Semester 1: Week 2

DATE & TIMEVENUESTAFFEVENT
Tuesday
26-09-2017
16:00 to 17:00
Medical and Biological Sciences Building
Tutorial Room 12
Dr Uli Schwarz-Linek

Lecture L3: Bacterial secretion systems II
2017-8_BL4215_L3

Semester 1: Week 3

DATE & TIMEVENUESTAFFEVENT
Monday
02-10-2017
16:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L4: Phagocytosis and invasion I
2017-8_BL4215_L4
Thursday
05-10-2017
15:00 to 16:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L5: Phagocytosis and invasion II
2017-8_BL4215_L5

Semester 1: Week 7

DATE & TIMEVENUESTAFFEVENT
Tuesday
31-10-2017
16:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L6: Pili I
2017-8_BL4215_L6
Friday
03-11-2017
16:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L7: Pili II
2017-8_BL4215_L7

Semester 1: Week 8

DATE & TIMEVENUESTAFFEVENT
Monday
06-11-2017
16:00 to 17:00
Medical and Biological Sciences Building
Tutorial Room 13
Dr Uli Schwarz-Linek

Lecture L8: TIE proteins: chemical harpoons
2017-8_BL4215_L8
Thursday
09-11-2017
16:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Lecture L9: t.b.a.
2017-8_BL4215_L9

Semester 1: Week 10

DATE & TIMEVENUESTAFFEVENT
Tuesday
21-11-2017
14:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Other O1: Student presentations I
2017-8_BL4215_O1
Wednesday
22-11-2017
14:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Other O2: Student presentations II
2017-8_BL4215_O2
Thursday
23-11-2017
14:00 to 17:00
Biomolecular Sciences Building
Lecture Theatre
Dr Uli Schwarz-Linek

Other O3: Student presentations III
2017-8_BL4215_O3
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL4215: Reading List

Click for BL4215 reading list

BL4215: Assessment

1.5-hour Written Examination = 40%, Coursework = 60%*

Assessment:
Essay
Due by:
30/10/2017 12:00
Feedback due by:
20/11/2017 12:00
Type:
Single Upload
Weight:
1%
Assessment:
Talk
Due by:
21/11/2017 13:00
Feedback due by:
12/12/2017 13:00
Type:
Single Upload
Weight:
1%

(MMS assessment data cached: 20 September 2017 22:20:10.)


The following related information applies to all Biology modules:

School of Biology Marking Criteria: See School of Biology Undergraduate Handbook
Late submission of continuous assessment work:

All late submissions of coursework that do not require electronic submission should be made via the late submissions box in the Biomolecular Science Building (beside the Teaching Office)
Exam details: See School of Biology Undergraduate Handbook
Exam timetable: see http://www.st-andrews.ac.uk/students/academic/examinations/examtimetablescurrent/
Expected attendance: See School of Biology Undergraduate Handbook for detailed attendance requirements.
Good Academic Practice & Avoiding Academic Misconduct: See School of Biology Undergraduate Handbook
University Student Handbook: University Student Handbook
School and University regulations in the School and University Undergraduate Handbook relating to absence reporting, penalties and rules for late submission of work, extensions for coursework, return of coursework, S-coding, good academic practice and Academic Alerts.: School of Biology Undergraduate Handbook University Student Handbook
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Who to ask

(Information in this section applies to all Biology Modules)

Questions about different aspects of the module should be directed to different people:

Questions about Contact
General teaching matters Biology Teaching Office ( bioteach@st-andrews.ac.uk )
Rescheduled or cancelled events Check your University email
Lecture or practical content The lecturer who presented the material
Completing assessed practical assignments The lecturer who set the assignment
Completing assessments Module Organiser (Dr Uli Schwarz-Linek us6@st-andrews.ac.uk)
Marking on continuous assessment The Demonstrator or Module Organiser (Dr Uli Schwarz-Linek us6@st-andrews.ac.uk)
Marking on exams Module Organiser (Dr Uli Schwarz-Linek us6@st-andrews.ac.uk)
Rearranging practical days Grant Brown
Absence and/or extensions Module Organiser (Dr Uli Schwarz-Linek us6@st-andrews.ac.uk) and the Biology Teaching Office ( bioteach@st-andrews.ac.uk )

Difficulties with academic progress which impact more than one module:

Year Coordinator

See School of Biology Undergraduate student handbook for list: http://biology.st-andrews.ac.uk/documents/UndergraduateHandbook.pdf

Overall performance, progress or future directions:

Advisor of Studies

Disability:

Disability Coordinator (Dr Jacqueline Nairn jn37@st-andrews.ac.uk)

Biology Teaching Office:

Room 1.17, Biomolecular Sciences Building, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST

Email: bioteach@st-andrews.ac.uk

Tel: 01334 463602

BL4215: Contributing Staff

Dr Uli Schwarz-Linek

Dr Uli Schwarz-Linek
(Module Organiser)

Lecturer in Biomolecular Sciencesus6@st-andrews.ac.uk
Dr Uli Schwarz-LinekDr Uli Schwarz-Linek
(Module Organiser)
Lecturer in Biomolecular Sciencesus6@st-andrews.ac.uk
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL4215: Learning Outcomes

This module is an introduction to the molecular basis of bacterial virulence. It aims to impart an appreciation of the role of molecular and structural biology in infectious disease research.

Students completing module BL4215 successfully should be able to:

  • Definition and classes of bacterial virulence factors
  • Appreciate the role of structural biology in understanding bacterial pathogenicity
  • Understand the function and mechanisms of Gram-negative secretion systems
  • Learn how bacterial surface-associated proteins trigger or prevent phagocytosis
  • Gain insights into the latest findings regarding structure and function of bacterial pili and adhesins
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL4215: Acquired Skills

Practical Skills

    Transferable Skills

    • Long individual presentation on given topic (>15 min)
    • Long essay (>2000 words)
    • Finding literature
    • Referencing
    • Searching databases
    • Peer assessment
    Data Sources: information in this online module handbook is gathered from several sources.
    Small footnote marks beside content, or by section titles indicate the source.
    * University of St Andrews Module Catalogue
    School of Biology Symbiosis Database (module organisers only)
    University of St Andrews MMS (St Andrews users only)

    Policies

    (Information in this section applies to all Biology Modules)