Selected Recent Publications

Ferguson MA, Brimacombe JS, Brown JR, Crossman A, Dix A, Field RA, Güther ML, Milne KG, Sharma DK, Smith TK. 1999. The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness. Biochimica et Biophysica Acta, Vol 1455, pp 327-340

Nagamune K, Nozaki T, Maeda Y, Ohishi K, Fukuma T, Hara T, Schwarz RT, Sutterlin C, Brun R, Riezman H, Kinoshita T. 2000. Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei. Proceedings of the National Academy of Sciences, Vol 12, pp 10336-10341.

Chang T, Milne KG, Güther ML, Smith TK, Ferguson MA. 2002. Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite. The Journal of Biological Chemistry, Vol 277, pp 50176-50182.

Smith TK, Crossman A, Brimacombe JS, Ferguson MA. Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness. 2004. EMBO Journal, Vol 23, pp 4701-4708

Smith TK, Crossman A, Borissow CN, Paterson MJ, Dix A, Brimacombe JS, Ferguson MA. Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors. 2001. EMBO Journal, Vol 20, pp 3322-32.

Smith TK, Crossman A, Paterson MJ, Borissow CN, Brimacombe JS, Ferguson MA. Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in Trypanosoma brucei and HeLa cells. 2002. The Journal of Biological Chemistry. Vol 277, pp 37147-53.