Dr Uli Schwarz-Linek:
Lecturer in Biomolecular Sciences

Dr Uli Schwarz-Linek

Dr Uli Schwarz-Linek
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST

tel: 01334 467188
fax: 01334 462595
room: B210

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School of Biology
Centre for Magnetic Resonance
Biomedical Sciences Research Complex

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Our research is directed at understanding structure, mechanism of host protein recognition and function of bacterial and viral virulence factors, with an emphasis on Gram-positive bacterial surface proteins. My group specialises in structural biology and protein biochemistry, complemented with biophysical and cell-based techniques. We have a particular interest in TIE (thioester, isopeptide, ester domain) proteins of Gram-positive pathogens including group A streptococci, vancomycin-resistant enterococci, Bacillus anthracis and Clostridium difficile. Our most significant contribution to the field was the discovery of bacteria-encoded, TIE protein-mediated covalent binding as a novel molecular principle in host-microbe interactions. The lab also exploits TIE domains for protein engineering to develop molecular tools for diagnostics, therapy and nanotechnology. Another focus of the group is the structural characterization of GAS M proteins, and the analysis of molecular mechanisms of post-streptococcal rheumatic sequelae. We also investigate structure and functions of single strand RNA virus NSs proteins, key virulence factors of a large class of clinically and economically important pathogens, with a focus on Rift Valley fever phlebovirus.


source: symbiosis

Recent Publications:

Recent publications listed in research@st-andrews
Walden, M, Edwards, JM, Dziewulska, AM, Bergmann, R, Saalbach, G, Kan, S-Y, Miller, OK, Weckener, M, Jackson, RJ, Shirran, SL, Botting, CH, Florence, GJ, Rohde, M, Banfield, MJ & Schwarz-Linek, U 2015, 'An internal thioester in a pathogen surface protein mediates covalent host binding' eLife, vol 4, e06638. DOI: 10.7554/eLife.06638
Houssen, WE, Bent, AF, McEwan, AR, Pieiller, N, Tabudravu, J, Koehnke, J, Mann, G, Adaba, RI, Thomas, L, Hawas, UW, Liu, H, Schwarz-Linek, U, Smith, MCM, Naismith, JH & Jaspars, M 2014, 'An efficient method for the in vitro production of Azol(in)e-based cyclic peptides' Angewandte Chemie International Edition, vol 53, no. 51, pp. 14171-14174. DOI: 10.1002/anie.201408082