Profile

Dr Uli Schwarz-Linek:
Senior Lecturer

Dr Uli Schwarz-Linek

Dr Uli Schwarz-Linek
Biomedical Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK

tel: 01334 467188
fax: 01334 462595
room: B210
email: us6@st-andrews.ac.uk

Related Content:



School of Biology
Centre for Magnetic Resonance
Biomedical Sciences Research Complex

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Our research is directed at understanding structure, mechanism of host protein recognition and function of bacterial and viral virulence factors, with an emphasis on Gram-positive bacterial surface proteins. My group specialises in structural biology and protein biochemistry, complemented with biophysical and cell-based techniques. We have a particular interest in TIE (thioester, isopeptide, ester domain) proteins of Gram-positive pathogens including group A streptococci, vancomycin-resistant enterococci, Bacillus anthracis and Clostridium difficile. Our most significant contribution to the field was the discovery of bacteria-encoded, TIE protein-mediated covalent binding as a novel molecular principle in host-microbe interactions. The lab also exploits TIE domains for protein engineering to develop molecular tools for diagnostics, therapy and nanotechnology. Another focus of the group is the structural characterization of GAS M proteins, and the analysis of molecular mechanisms of post-streptococcal rheumatic sequelae. We also investigate structure and functions of single strand RNA virus NSs proteins, key virulence factors of a large class of clinically and economically important pathogens, with a focus on Rift Valley fever phlebovirus.

 



source: symbiosis


Recent Publications:

Recent publications


5  (of 33 published available) for us6. (source: University of St Andrews PURE)
Please click title of any item for full details.

2018 (16/10)
Biochemistry
vol.57 pp.5996-6002
(Article)
2017 (12)
Protein Engineering, Design & Selection
vol.30 pp.771-780
(Article)
2017 (15/9)
eLife
vol.6 
(Article)
2015
eLife
vol.4 
(Article)
An internal thioester in a pathogen surface protein mediates covalent host binding
Miriam Walden, John Michael Edwards, Rene Bergmann, Gerhard Saalbach, Rosemary J. Jackson, Sally Lorna Shirran, Catherine Helen Botting, Gordon John Florence, Manfred Rohde, Mark J. Banfield, Uli Schwarz-Linek 
Keywords: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium perfringens, Host-microbe interactions, Fibrinogen, Bacterial surface proteinsQH301 Biology, QR MicrobiologyDAS