Profile

Dr Uli Schwarz-Linek:
Lecturer in Biomolecular Sciences

Dr Uli Schwarz-Linek

Dr Uli Schwarz-Linek
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK

tel: 01334 467188
fax: 01334 462595
room: B210
email: us6@st-andrews.ac.uk

Related Content:

research@st-andrews

Biology Management Group
School of Biology
Biology Postgraduate Recruitment Committee
Centre for Magnetic Resonance
Biomedical Sciences Research Complex

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We investigate the molecular basis for the subversion of host cell signalling and uptake processes by Streptococcus pyogenes and the autoimmune response triggered by some streptococcal infections. This remarkably versatile and important human pathogen causes a wide range of diseases including pharyngitis, impetigo, glomerulonephritis, rheumatic heart disease, necrotising fasciitis and toxic shock syndrome. The conservative estimate of 500000 deaths per annum places Streptococcus pyogenes among the major human pathogens (WHO report 2004). The complex pathogenicity of streptococci is reflected by the expression of a multitude of virulence factors. We currently focus on three cell-wall anchored proteins, SfbI, FbaB and the M protein. These proteins play a role in the persistence of streptococcal infections, invasive infections and the development of rheumatogenic sequelae, respectively. We use a range of biophysical techniques, most importantly NMR spectroscopy and microcalorimetry, to understand the structures and molecular interactions of these bacterial virulence factors with human proteins. Ultimately, this research will contribute to the development of new strategies that are needed to tackle the enormous health burden of streptococcal diseases.

 



source: symbiosis


Recent Publications:

Recent publications listed in research@st-andrews
Walden, M, Edwards, JM, Dziewulska, AM, Bergmann, R, Saalbach, G, Kan, S-Y, Miller, OK, Weckener, M, Jackson, RJ, Shirran, SL, Botting, CH, Florence, GJ, Rohde, M, Banfield, MJ & Schwarz-Linek, U 2015, 'An internal thioester in a pathogen surface protein mediates covalent host binding' eLife, vol 4, e06638. DOI: 10.7554/eLife.06638
Houssen, WE, Bent, AF, McEwan, AR, Pieiller, N, Tabudravu, J, Koehnke, J, Mann, G, Adaba, RI, Thomas, L, Hawas, UW, Liu, H, Schwarz-Linek, U, Smith, MCM, Naismith, JH & Jaspars, M 2014, 'An efficient method for the in vitro production of Azol(in)e-based cyclic peptides' Angewandte Chemie International Edition, vol 53, no. 51, pp. 14171-14174. DOI: 10.1002/anie.201408082