Profile

Dr Tracey Gloster:
Lecturer



I am interested in the structure and function of eukaryotic carbohydrate processing enzymes. Obtaining a greater appreciation of how these enzymes assimilate or degrade carbohydrates is important in understanding the biological roles that carbohydrates play in cellular processes, and also how these processes malfunction in a number of diseases, such as cancer, lysosomal storage disorders, and neurodegenerative diseases.

I am currently investigating the enzymes responsible for the degradation of heparan sulphate, a component of the extracellular matrix. Using a combination of approaches, including molecular biology, protein production, X-ray crystallography, enzyme kinetics and cell culture, I aim to gain a greater understanding of these enzymes from a mechanistic and structural perspective. Hopefully this will lead to the development of tools, such as enzyme inhibitors, that can be used to probe the biological functions of the enzymes, and possibly also for therapeutic applications in the longer term.

 



I am interested in the structure and function of eukaryotic carbohydrate processing enzymes. Obtaining a greater appreciation of how these enzymes assimilate or degrade carbohydrates is important in understanding the biological roles that carbohydrates play in cellular processes, and also how these processes malfunction in a number of diseases, such as cancer, lysosomal storage disorders, and neurodegenerative diseases.

I am currently investigating the enzymes responsible for the degradation of heparan sulphate, a component of the extracellular matrix. Using a combination of approaches, including molecular biology, protein production, X-ray crystallography, enzyme kinetics and cell culture, I aim to gain a greater understanding of these enzymes from a mechanistic and structural perspective. Hopefully this will lead to the development of tools, such as enzyme inhibitors, that can be used to probe the biological functions of the enzymes, and possibly also for therapeutic applications in the longer term.

source: symbiosis


Recent Publications:

Recent publications


5  (of 49 published available) for tmg. (source: University of St Andrews PURE)
Please click title of any item for full details.

2018 (25/6)
Angewandte Chemie International Edition
vol.57 pp.7644-7648
(Article)
2018 (13/8)
Nature Communications
vol.9 
(Article)
Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
Weiwu Ren, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katazyna Swiderek, Vincent Moliner, Robert Britton, Tracey Gloster, Andrew Bennet 
Keywords: QH301 Biology, QD ChemistryDAS
2017 (1/8)
Protein & Peptide Letters
vol.24 pp.710-722
(Review article)
2016 (17/5)
Biochemistry
vol.55 pp.2753-2747
(Article)
Mechanism of the human nucleocytoplasmic hexosaminidase D
Matthew G Alteen, Verena Oehler, Ivana Nemčovičová, Iain B H Wilson, David J Vacadlo, Tracey Gloster 
Keywords: Hexosaminidase, Glycoside hydrolase, Enzyme kinetics, Enzyme mechanism, Enzyme inhibition, Substrate-assisted catalysisQD Chemistry, QH301 Biology
2016 (21/11)
Angewandte Chemie International Edition
vol.55 pp.14978-14982
(Article)