Dr Rona Ramsay:
Dr Rona Ramsay
Biomolecular Sciences Building
University of St Andrews
tel: 01334 463411
fax: 01334 462595
room: 358 (Purdie)
School of Biology
Biomedical Sciences Research Complex
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Enzymology involves the structural and functional characterisation of proteins and their interactions either in the cell or in purified form. Techniques of kinetic analysis, spectroscopy, structural determination, inhibitor studies, and molecular biology are combined to investigate how enzymes work. We study particularly membrane bound mitochondrial enzymes such as monamine oxidases (the target of antidepressants) and the carnitine acyltransferases that modulate fat metabolism.
Enzymology involves the structural and functional characterisation of proteins either in the cell or in purified form. Techniques of kinetic analysis, spectroscopy, structural determination, inhibitor studies, and molecular biology are combined to investigate how enzymes work.
We study particularly membrane bound mitochondrial enzymes. For example, mitochondrial monoamine oxidases A and B (MAO A and MAO B) are ubiquitous homodimeric FAD-containin oxidases that catalyse the oxidation of biogenic amines. Both enzymes play a vital role in the regulation of neurotransmitter levels in brain below) complement mechanistic studies of purified MAO A and its mutants to characterise the active site and the catalytic mechanism of the enzyme to aid in drug design.
At the cellular level, investigating a family of homologous enzymes such as the carnitine
acyltransferases permits investigation of the molecular basis of regulation. Different
members of this family mediate fatty acid trafficking and influence pathways such as
ketogenesis, lipid synthesis and membrane repair (see scheme below). Current projects
include characterisation of the active sites of the acyltransferases by kinetic and mutagenic
techniques concurrent with crystallisation trials and, at a cellular level, a study of fluorescent
fusion proteins to investigate cellular trafficking.
Honorary Fellow, Hannah Research Institute, Ayr, Scotland
Visiting Professor, Graduate Programme, University of Catania (2002-2006)
Basic Research Grant Panel, Science and Innovation, Enterprise Ireland (2002-4).
Presenter and Co-ordinator for Athena Women in Science events (from 2000).
Participant, Contemporary Poetry, Contemporary Science, Wellcome Trust
5 (of 76 published available) for rrr. (source: University of St Andrews PURE)
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Clinical and Translational Medicine
Rona R. Ramsay, Marija R. Popovic-Nikolicb, Katarina Nikolic, Elisa Uliassi, Maria Laura Bolognesi
Keywords: Multi-target drugs, Neurodegeneration, Cancer, Cheminformatics, Virtual screening, Biological assaysRM Therapeutics. Pharmacology, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, RC0254 Neoplasms. Tumors. Oncology (including Cancer), QD Chemistry
Frontiers in Chemistry
Alen Albreht, Irena Vovk, Janez Mavri, Jose Marco-Contelles, Rona R. Ramsay
Keywords: Monoamine oxidase, Propargylamine, Inhibition mechanism, Electrostatic interactions, Quantum chemical calculations, Isomers, Interconversion, StructureQD Chemistry, RM Therapeutics. PharmacologyNDAS
Rona R. Ramsay, Keith F. Tipton
Keywords: Alzheimer’s disease, l-deprenyl (selegiline), Donepezil, Galantamine, Inhibitor constant, Enzyme inhibition, Multitarget-directed ligand (MTDL), Rasagiline, RivastigmineQH301 Biology, QH426 Genetics, RM Therapeutics. PharmacologyBiochemistry, Chemistry (miscellaneous)
Stefanie Hagenow, A. Stasiak, Rona R. Ramsay, Holger Stark
Keywords: Histamine H3 receptors, Monoamine oxidase, Inverse agonist/antagonist, Dual-target ligandRC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, RM Therapeutics. PharmacologyPharmacologyNDAS
ACS Chemical Neuroscience
Philippe De Deurwaerdère, Claudia Binda, Rémi Corne, Cosima Leone, Aurora Valeri, Massimo Valoti, Rona R. Ramsay, Yagamare Fall, Jose Marco-Contelles
Keywords: Propargylamines, Crystallography, Monoamine, Neurochemistry, Neuroprotection, Alzheimer's disease, EnzymologyQD Chemistry, QH301 Biology, RC0321 Neuroscience. Biological psychiatry. NeuropsychiatryNDAS