Profile

Dr Marcus Bischoff:
Lecturer

Dr Marcus Bischoff

Dr Marcus Bischoff
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK

tel: 01334 467199
fax: 01334 462595
room: B115
email: mb273@st-andrews.ac.uk

Related Content:

research@st-andrews
Bischoff Lab Website

School of Biology
Biomedical Sciences Research Complex

edit mb273 details


We are interested in how shape and form arise during animal development. During morphogenesis, cells interpret complex information and react accordingly to shape tissues and organs. Here, many cell behaviours, such as cell migration and cell shape changes, work together. Despite recent progress, it still remains mysterious how all these behaviours are regulated and coordinated.

To study cell behaviours in the living organism, we use the morphogenesis of the adult abdominal epidermis of Drosophila. Employing a combination of in vivo 4D microscopy and sophisticated genetic tools, we observe and quantify all cell behaviours after experimental manipulation of the system. We have two major areas of interest: (1) What are the signals that instruct the cells to execute certain behaviours during morphogenesis? (2) How do cells translate these signals into specific actions, such as migration and constriction? Addressing these questions will enable us to gain a deeper understanding of morphogenetic processes and the underlying cell behaviours as well as of how the mechanical forces that ultimately drive morphogenesis are created. These insights will be of widespread relevance, since the (mis-) regulation of cell behaviour is also fundamental to wound repair and numerous diseases, including cancer.

 



source: symbiosis


Recent Publications:

Recent publications listed in research@st-andrews
Seijo, I, Guerrero, I & Bischoff, M 2015, In Vivo Imaging of Hedgehog Transport in Drosophila Epithelia. in N Riobo (ed.), Methods in Molecular Biology: Hedgehog Signalling Protocols. vol. 1322, Springer Science and Business Media. DOI: 10.1007/978-1-4939-2772-2_2
Gradilla, A-C, González, E, Seijo, I, Andrés, G, Bischoff, M, González-Mendez, L, Sánchez, V, Callejo, A, Ibáñez, C, Guerra, M, Ortigão-Farias, JR, Sutherland, JD, González, M, Barrio, R, Falcón-Pérez, JM & Guerrero, I 2014, 'Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion' Nature Communications, vol 5, pp. 5649. DOI: 10.1038/ncomms6649
Bischoff, M, Gradilla, A-C, Seijo, I, Andres, G, Rodriguez-Navas, C, Gonzalez-Mendez, L & Guerrero, I 2013, 'Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia' Nature Cell Biology, vol 15, pp. 1269-1281. DOI: 10.1038/ncb2856