Profile

Dr Carlos Penedo-Esteiro:
Lecturer


Dr Carlos Penedo-Esteiro
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK

tel: 01334 463106
fax: 01334 462595
room: B108
email: jcp10@st-andrews.ac.uk

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School of Biology
School of Physics and Astronomy
Biomedical Sciences Research Complex

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We are interested in the use and development of novel biophysical techniques to study biomolecular interactions including proteins, DNA and RNA at the level of individual molecules. The advantages of single-molecule detection are many, apart from the fascination of looking at individual biomolecules at work, single-molecule techniques can measure intermediates and follow time-dependent pathways of chemical reactions and folding mechanisms that are difficult or impossible to synchronize at the ensemble level. Thus, single-molecule techniques provide novel insights into how molecules and systems behave, having the advantage that spatial and temporal averaging is avoided, temporal synchronisation is not necessary and novel phenomena, which otherwise are averaged and remain hidden in ensembles, may be discovered. Our aim is to monitor, in real-time, the behaviour of individual biological molecules and complexes, in vitro and in live cells. By combining the dynamic information obtained at the single-molecule or single-complex level with structural and biochemical analyses, we hope to create "molecular movies" of biological processes and from them obtain a deeper understanding of these processes.

http://www.st-andrews.ac.uk/~singlemol/singlemol.html

 



source: symbiosis


Recent Publications:

5 (of 33 published available) for jcp10 (source: University of St Andrews PURE)
Please click title of any item for full details

Twin-FRET Sankar Jana, Marta Diez-Castellnou, Euan Robert Kay, Carlos Penedo
Biophysical Journal 2019 vol.116 pp.565A-565A
Unprecedented tunability of riboswitch structure and regulatory function by sub-millimolar variations in physiological Mg2+ Julien Boudreault, Patrick S-Pierre, Adrien Chauvier, Adrien Rizzi, Pascale B Beauregard, Daniel A Lafontaine, Carlos Penedo
Nucleic Acids Research
Real-time observation of conformational switching in single conjugated polymer chains S fronk, G Bazan, Ifor David William Samuel, Carlos Penedo
Science Advances 2018 vol.4
An integrated perspective on RNA aptamer ligand-recognition models Carlos Penedo
Physical Chemistry Chemical Physics 2017 vol.19 pp.6921-6932
DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain Sarah J Northall, Ryan Buckley, Nathan Jones, Carlos Penedo, Panos Soultanas, Edward Bolt
DNA Repair 2017 vol.57 pp.125-132