Profile

Prof David Evans:
Professor

Prof David Evans

Prof David Evans
Biomolecular Sciences Building
University of St Andrews
North Haugh
St Andrews
KY16 9ST
Fife
UK

tel: 01334 46 3396
fax:
room: 2.11
email: dje2@st-andrews.ac.uk

Related Content:

research@st-andrews
Evans lab web pages

School of Biology
Biomedical Sciences Research Complex

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I am a virologist studying the biology of single stranded positive sense RNA viruses, including poliovirus, hepatitis C virus and deformed wing virus of honeybees. My current research focuses on the evolution, replication and pathogenesis of these viruses. 

Poliovirus no longer causes significant human mortality but is an exceptionally well characterised virus we use to study the molecular mechanism of recombination, an important evolutionary process exhibited by many other single stranded postiive sense RNA viruses. Our recent studies have demonstrated that recombination is a biphasic process, involving both a strand exchange recombination event and a secondary resolution event. The characteristics of intermediates in this event may explain 'evolution by duplication' in RNA viruses, in which partial regions of the genome become duplicated and then evolve independently.

Deformed wing virus (DWV) is the most important virus infecting honeybees and is responsible for the majority of overwintering colony losses. DWV is transmitted during feeding by the ectoparasitic mite Varroa to developing honeybee pupae. We have shown that mite-exposed pupae contain a near-clonal population of DWV present at very high levels. In contrast, pupae that have not been exposed to mites contain a low level of a highly diverse DWV population. We are currently investigating the molecular pathogenesis of the virulent strain of DWV and developing strategies to control the virus. 

 



We study the biology of a range of viruses with single stranded, positive sense RNA genomes that are of medical importance, that provide tractable model systems or that are important in food security. Our current research focuses on the replication and evolution of poliovirus and the biology of deformed wing virus of honeybees.

source: symbiosis


Recent Publications:

Recent publications listed in research@st-andrews
Puxty, RJ, Millard, AD, Evans, DJ & Scanlan, DJ 2016, 'Viruses inhibit CO2 fixation in the most abundant phototrophs on Earth' Current Biology, vol 26, no. 12, pp. 1585-1589. DOI: 10.1016/j.cub.2016.04.036
Puxty, RJ, Perez-Sepulveda, B, Rihtman, B, Evans, DJ, Millard, AD & Scanlan, DJ 2015, 'Spontaneous deletion of an "ORFanage" region facilitates host adaptation in a "photosynthetic" cyanophage' PLoS One, vol 10, no. 7, e0132642. DOI: 10.1371/journal.pone.0132642