Profile

Dr Dave Ferrier:
Reader in Biology and Deputy Director of the Scottish Oceans Institute



We aim to understand how the diversity of form in the animal kingdom evolved. The focus of our research is the connection between the evolution of animal genome organisation and development, with a particular concentration on the homeobox-containing genes. The Hox gene cluster is established as a corner-stone of Evolutionary Developmental Biology, but much about the evolution of its organisation and mode of operation remains unknown. Also the Hox cluster is not unique as a homeobox gene cluster controlling animal development, further clusters being the ParaHox and NK clusters, all of which evolved within larger arrays of homeobox genes (the Mega-cluster and Super-Hox cluster). We utilize a variety of organisms in our research (including amphioxus, sea squirts, polychaetes and priapulids), chosen from key points in the phylogeny of the animals to enable reconstruction of the ancestral conditions at major nodes in the animal kingdom; the origin of bilaterians, protostomes, deuterostomes, chordates and vertebrates. 

 



Research Overview. We aim to understand how the diversity of form in the animal kingdom evolved. The focus of our research is the connection between the evolution of animal genome organisation and development, with a particular concentration on the homeobox-containing genes. The Hox gene cluster is established as a corner-stone of Evolutionary Developmental Biology, but much about the evolution of its organisation and mode of operation remains unknown. Also the Hox cluster is not unique as a homeobox gene cluster controlling animal development, further clusters being the ParaHox and NK clusters, all of which evolved within larger arrays of homeobox genes (the Mega-cluster, Giga-cluster and Super-Hox cluster). We utilize a variety of organisms in our research (including amphioxus, sea squirts, polychaetes and priapulids), chosen from key points in the phylogeny of the animals to enable reconstruction of the ancestral conditions at major nodes in the animal kingdom; the origin of bilaterians, protostomes, deuterostomes, chordates and vertebrates, as well as the origin of the entire animal kingdom. Knowledge of such ancestors is vital in understanding subsequent diversification.

source: symbiosis


Recent Publications:

Recent publications


5  (of 76 published available) for dekf. (source: University of St Andrews PURE)
Please click title of any item for full details.

2018 (1)
Development Genes and Evolution
vol.228 pp.13-30
(Article)
2018 (2/5)
Science Advances
vol.4 
(Article)
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals
Naoki Kabeya, Miguel Fonseca, David Ellard Keith Ferrier, Juan Navarro, Line Bay, David Francis, Douglas Tocher, Filipe Castro, Oscar Monroig 
Keywords: QH301 Biology, QH426 Genetics, SH Aquaculture. Fisheries. AnglingDAS
2018 (22/10)
Current Biology
vol.28 pp.R1208-R1210
(Review article)
Genome biology
David Ellard Keith Ferrier, Shunsuke Sogabe 
2018 (1/11)
BMC Biology
vol.16 
(Article)