Dr Samantha Pitt has been elected as a board member of the International Society for Zinc Biology (http://iszb.org/). She will serve the Society for 2 years. She is very excited to contribute towards the future direction of the Society and will work to raise the awareness of the scientific community regarding the importance of zinc in health and disease.
The Metal Ions in Medicine group would like to say a big congratulations to (Dr) Amelie Sobczak on passing her PhD viva!!
The Metal Ions in Medicine group would like to say a big congratulations to Gavin Robertson on passing his PhD viva.
Dr Alan Stewart represented the Metal Ions in Medicine team at the Obesity and Diabetes Conference in Rome held between 25th-26th Februray 2019. Whilst there he gave a keynote talk titled “Influence of free fatty acids on plasma zinc handling by albumin: Impact on coagulation in diabetes”. As an organising committe member he would like to thank all who attended and presented during the meeting.
Dendritic cells are key immune cells that respond to pathogens and co-ordinate many innate and adaptive immune responses. Dr Swati Arya and Dr Dagmara Wiatrek-Moumoulidis from the Stewart group, together with Dr Simon Powis and researchers from the Mass Spectrometry team in St Andrews (led Dr Sally Shirran) have used SWATH-MS to quantitively measure proteomic changes that occur in monocyte-derived dendritic cells (moDCs) following activation by lipopolysaccharide (LPS). A moDC library of 4,666 proteins was generated and proteins were quantified at 0, 6 and 24 h post-LPS stimulation using SWATH-MS. Functional annotation of proteins exhibiting significant changes in expression between the various time points led to the identification of clusters of proteins implicated in distinct cellular processes including interferon and interleukin signalling, endocytosis, the ER-phagosome pathway and antigen-presentation. This study provides new detailed insight into the global proteomic changes that occur in moDCs during antigen processing and presentation and further demonstrate the potential of SWATH-MS for the quantitative study of proteins involved in cellular processes. This work will be published in the online open-access journal, Scientific Reports.