7th International Caparica Conference on Analytical Proteomics (ICAP)

On the 14th July Dr Alan Stewart gave an online invited talk at the 7th International Caparica Conference on Analytical Proteomics (ICAP), 2021 held in Lisbon, Portugal. The talk was entitled “Plasma fatty acid levels control circulatory zinc speciation: Relevance to pro-coagulatory disorders from speciomic and lipidomic studies”. He would like to thank the organisers, especially Prof Capelo for (as always!) a really exciting and engaging meeting.

£1M UKRI-BBSRC/FAPESP Grant Award to Alan Stewart: A “speciomic” toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects

Dr Alan Stewart has been awarded £978,876 from the BBSRC to fund a new bilateral project entitled “A “speciomic” toolkit to investigate fatty acid-mediated changes in plasma zinc speciation and their physiological effects”. The work will be a collaboration between researchers at the Universities of St Andrews, Warwick in the UK and Campinas in Brazil. The project, which Dr Stewart will lead, has been awarded additional funding from FAPESP (The São Paulo Research Foundation) to support the work in Brazil. As part of this study, state-of-the-art and bespoke analytical methods will be employed to understand the (re)distribution of zinc within plasma in the presence of high concentrations of fatty acids, mirroring conditions observed in disease states. The impact of this dynamic on physiological processes including insulin signalling and cellular zinc uptake will also be examined. Prof Claudia Blindauer will oversee work at the University of Warwick and Profs Marco Arruda and Carlos Ramos the research at University of Campinas.

British Heart Foundation – Lunch and Learn Talk

On the 15th June 2021, Dr Alan Stewart gave a Lunch and Learn talk for the British Heart Foundation based upon his research.

The talk was entitled “Could zinc be the key to new diabetes treatments?” and featured a small quiz. The audience was made up of fundraisers and other BHF staff based throughout the UK.

Fatty acids influence blood clotting through modulation of plasma zinc – new publication in Chemical Science

The Metal Ions in Medicine group have just published new data that may shed light on how fats in your blood could affect your health. The paper entitled “Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes” has just been accepted for publication in the high impact journal, Chemical Science. In this study, it was found that free fatty acids  influence certain blood clotting characteristics including parameters relating to fibrin clot formation as well as platelet aggregation. It was found that the mechanism of action most likely involves reduction of zinc binding to the protein, serum albumin (the main zinc and fatty acid carrier protein in the blood) and a consequent increase in binding of zinc to proteins that regulate clot formation. The study suggests that this mechanism may contribute to pathogenic clot formation, which is more frequently observed in individuals with disease states marked by elevated plasma fatty acid levels, such as type-2 diabetes, obesity and fatty liver disease.

BioMetals 2020 Meeting

Dr Alan Stewart would like to thank Dr Isabelle Michaud-Soret and all the other organisers of the BioMetals 2020 Meeting which was held between the 6th -10th July 2020. The meeting was originally meant to take place in Grenoble, France but was switched to an online meeting due to the ongoing Covid-19 Pandemic. The meeting was well attended – with over 150 delegates from all over the world. Alan gave a talk on his group’s work entitled “Metal ion dyshomeostasis and coagulatory defects in type-1 and type-2 diabetes”.