Tenovus Scotland Grant Award

Dr Alan Stewart, Dr Swati Arya and Dr Peter Caie have been awarded a £89,415 grant from Tenovus Scotland for a new project entitled “Assessment of the predictive value of plasma proteins in oesophageal adenocarcinoma treatment”. The funding will support a PhD studentship due to start later in the year. Applications are now open to candidates who are interested in applying for this studentship. They must hold a first or upper-second class degree (and/or an MSc/MRes degree) in Molecular & Cellular Biology, Biochemistry, Chemistry (Analytical) or a related subject from a recognised academic institution. Full details are available here.

Alan Stewart joins the Editorial Board of Scientific Reports

Dr Alan Stewart has been appointed to the editorial board of the journal, Scientific Reports – an online open access “mega journal” from the publishers of Nature. The journal publishes scientifically valid primary research from all areas of the natural and clinical sciences. Alan will serve on the journal’s Chemical Biology board.

Obesity and Diabetes Conference, Rome, Italy

Dr Alan Stewart represented the Metal Ions in Medicine team at the Obesity and Diabetes Conference in Rome held between 25th-26th Februray 2019. Whilst there he gave a keynote talk titled “Influence of free fatty acids on plasma zinc handling by albumin: Impact on coagulation in diabetes”. As an organising committe member he would like to thank all who attended and presented during the meeting.

Quantitative proteomic changes in dendritic cells – paper to be published in Scientific Reports

Dendritic cells are key immune cells that respond to pathogens and co-ordinate many innate and adaptive immune responses. Dr Swati Arya and Dr Dagmara Wiatrek-Moumoulidis from the Stewart group, together with Dr Simon Powis and researchers from the Mass Spectrometry team in St Andrews (led Dr Sally Shirran) have used SWATH-MS to quantitively measure proteomic changes that occur in monocyte-derived dendritic cells (moDCs) following activation by lipopolysaccharide (LPS). A moDC library of 4,666 proteins was generated and proteins were quantified at 0, 6 and 24 h post-LPS stimulation using SWATH-MS. Functional annotation of proteins exhibiting significant changes in expression between the various time points led to the identification of clusters of proteins implicated in distinct cellular processes including interferon and interleukin signalling, endocytosis, the ER-phagosome pathway and antigen-presentation. This study provides new detailed insight into the global proteomic changes that occur in moDCs during antigen processing and presentation and further demonstrate the potential of SWATH-MS for the quantitative study of proteins involved in cellular processes. This work will be published in the online open-access journal, Scientific Reports.