Recent research publications:
- Kinetic and Structural Characterization of Sialidases (Kdnases) from Ascomycete Fungal Pathogens.
ACS Chem Biol. 2021 Nov 19;16(11):2632-2640. doi: 10.1021/acschembio.1c00666. Epub 2021 Nov 1.PMID: 34724608
- The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.
Nucleic Acids Res. 2021 Mar 18;49(5):2777-2789. doi: 10.1093/nar/gkab073.PMID: 33590098
- Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry.
ACS Catal. 2020 Dec 18;10(24):15019-15032. doi: 10.1021/acscatal.0c04736. Epub 2020 Dec 7.PMID: 33391858
- Foltanyi F, Hawkins JE, Panovic I, Bird EJ, Gloster TM, Lancefield CS & Westwood NJ. Analysis of the product streams obtained on butanosolv pretreatment of draff. Oct 2020, Biomass and Bioenergy. 141, 105680.
- Elife. 2020 Jun 29;9:e57627. doi: 10.7554/eLife.57627.PMID: 32597755
- Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate.
Nat Commun. 2020 Jan 24;11(1):500. doi: 10.1038/s41467-019-14222-x.PMID: 31980625
- An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.
Nature. 2020 Jan;577(7791):572-575. doi: 10.1038/s41586-019-1909-5. Epub 2020 Jan 15.PMID: 31942067
- Linear Eyring Plots Conceal a Change in the Rate-Limiting Step in an Enzyme Reaction.
Biochemistry. 2018 Dec 11;57(49):6757-6761. doi: 10.1021/acs.biochem.8b01099. Epub 2018 Nov 27.PMID: 30472832
- New Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes.
Chemistry. 2018 Dec 17;24(71):19081-19088. doi: 10.1002/chem.201804662. Epub 2018 Nov 26.PMID: 30307091
- Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Nat Commun. 2018 Aug 13;9(1):3243. doi: 10.1038/s41467-018-05702-7.PMID: 30104598
Selected reviews:
- Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity and Disease.
Front Mol Biosci. 2021 Jul 29;8:705133. doi: 10.3389/fmolb.2021.705133. eCollection 2021.PMID: 34395532
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Curr Opin Chem Biol. 2020 Apr;55:180-188. doi: 10.1016/j.cbpa.2020.01.015. Epub 2020 Mar 20.PMID: 32203896
- The Enzymatic Degradation of Heparan Sulfate.
Protein Pept Lett. 2017;24(8):710-722. doi: 10.2174/0929866524666170724113452.PMID: 28741461
- TM Gloster. Advances in understanding glycosyltransferases from a structural perspective, 2014, Curr Opin Struct Biol 28,131-41.
- TM Gloster. Development of inhibitors as research tools for carbohydrate-processing enzymes, 2012, Biochem Soc Trans, 40, 913-928.
- TM Gloster & DJ Vocadlo. Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology, 2012, Nat Chem Biol, 8, 683-694.
- TM Gloster & GJ Davies. Glycosidase inhibition: assessing mimicry of the transition state, 2010, Org Biomol Chem, 8, 305-320.
Selected research publications that highlights the type of work and techniques that are being used in the Gloster group:
- TM Gloster, WF Zandberg, JE Heinonen, DL Shen, L Deng & DJ Vocadlo. Hijacking a biosynthetic pathway yields a potent glycosyltransferase inhibitor acting in cells, 2011, Nat Chem Biol, 7, 174-181.
- TM Gloster, JP Turkenburg, JR Potts, B Henrissat & GJ Davies. Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora, 2008, Chem Biol, 15, 1058-1067.
- TM Gloster, P Meloncelli, RV Stick, DL Zechel, A Vasella & GJ Davies. Glycosidase inhibition: an assessment of the binding of eighteen putative transition-state mimics, 2007, J Am Chem Soc, 129, 2345-2354.
A full and up-to-date publication list for Tracey can be found on Google Scholar.