Recent research publications:

• Kinetic and Structural Characterization of Sialidases (Kdnases) from Ascomycete Fungal Pathogens.
  Nejatie A, Steves E, Gauthier N, Baker J, Nesbitt J, McMahon SA, Oehler V, Thornton NJ, Noyovitz B, Khazaei K, Byers BW, Zandberg WF, Gloster TM, Moore MM, Bennet AJ.ACS Chem Biol. 2021 Nov 19;16(11):2632-2640. doi: 10.1021/acschembio.1c00666. Epub 2021 Nov 1.PMID: 34724608
• The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence.
  Zhu W, McQuarrie S, Grüschow S, McMahon SA, Graham S, Gloster TM, White MF.Nucleic Acids Res. 2021 Mar 18;49(5):2777-2789. doi: 10.1093/nar/gkab073.PMID: 33590098
• Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry.
  Machado TFG, Purg M, McMahon SA, Read BJ, Oehler V, Åqvist J, Gloster TM, da Silva RG.ACS Catal. 2020 Dec 18;10(24):15019-15032. doi: 10.1021/acscatal.0c04736. Epub 2020 Dec 7.PMID: 33391858
• Foltanyi F, Hawkins JE, Panovic I, Bird EJ, Gloster TM, Lancefield CS & Westwood NJ. Analysis of the product streams obtained on butanosolv pretreatment of draff. Oct 2020, Biomass and Bioenergy. 141, 105680.
• Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage.
  Athukoralage JS, McQuarrie S, Grüschow S, Graham S, Gloster TM, White MF.Elife. 2020 Jun 29;9:e57627. doi: 10.7554/eLife.57627.PMID: 32597755
• Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate.
  McMahon SA, Zhu W, Graham S, Rambo R, White MF, Gloster TM.Nat Commun. 2020 Jan 24;11(1):500. doi: 10.1038/s41467-019-14222-x.PMID: 31980625
• An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity.
  Athukoralage JS, McMahon SA, Zhang C, Grüschow S, Graham S, Krupovic M, Whitaker RJ, Gloster TM, White MF.Nature. 2020 Jan;577(7791):572-575. doi: 10.1038/s41586-019-1909-5. Epub 2020 Jan 15.PMID: 31942067
• Linear Eyring Plots Conceal a Change in the Rate-Limiting Step in an Enzyme Reaction.
  Machado TFG, Gloster TM, da Silva RG.Biochemistry. 2018 Dec 11;57(49):6757-6761. doi: 10.1021/acs.biochem.8b01099. Epub 2018 Nov 27.PMID: 30472832
• New Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes.
  Artola M, Kuo CL, McMahon SA, Oehler V, Hansen T, van der Lienden M, He X, van den Elst H, Florea BI, Kermode AR, van der Marel GA, Gloster TM, Codée JDC, Overkleeft HS, Aerts JMFG.Chemistry. 2018 Dec 17;24(71):19081-19088. doi: 10.1002/chem.201804662. Epub 2018 Nov 26.PMID: 30307091
• Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
  Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Świderek K, Moliner V, Britton R, Gloster TM, Bennet AJ.Nat Commun. 2018 Aug 13;9(1):3243. doi: 10.1038/s41467-018-05702-7.PMID: 30104598

Selected reviews:

• Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity and Disease.
  Bowles WHD, Gloster TM.Front Mol Biosci. 2021 Jul 29;8:705133. doi: 10.3389/fmolb.2021.705133. eCollection 2021.PMID: 34395532
• Exploitation of carbohydrate processing enzymes in biocatalysis.
  Gloster TM.Curr Opin Chem Biol. 2020 Apr;55:180-188. doi: 10.1016/j.cbpa.2020.01.015. Epub 2020 Mar 20.PMID: 32203896
• The Enzymatic Degradation of Heparan Sulfate.
  Griffin LS, Gloster TM.Protein Pept Lett. 2017;24(8):710-722. doi: 10.2174/0929866524666170724113452.PMID: 28741461
• TM Gloster. Advances in understanding glycosyltransferases from a structural perspective, 2014, Curr Opin Struct Biol 28,131-41.
• TM Gloster. Development of inhibitors as research tools for carbohydrate-processing enzymes, 2012, Biochem Soc Trans, 40, 913-928.
• TM Gloster & DJ Vocadlo. Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology, 2012, Nat Chem Biol, 8, 683-694.
• TM Gloster & GJ Davies. Glycosidase inhibition: assessing mimicry of the transition state, 2010, Org Biomol Chem, 8, 305-320.

Selected research publications that highlights the type of work and techniques that are being used in the Gloster group:

• TM Gloster, WF Zandberg, JE Heinonen, DL Shen, L Deng & DJ Vocadlo. Hijacking a biosynthetic pathway yields a potent glycosyltransferase inhibitor acting in cells, 2011, Nat Chem Biol, 7, 174-181.
• TM Gloster, JP Turkenburg, JR Potts, B Henrissat & GJ Davies. Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora, 2008, Chem Biol, 15, 1058-1067.
• TM Gloster, P Meloncelli, RV Stick, DL Zechel, A Vasella & GJ Davies. Glycosidase inhibition: an assessment of the binding of eighteen putative transition-state mimics, 2007, J Am Chem Soc, 129, 2345-2354.

A full and up-to-date publication list for Tracey can be found on Google Scholar.