Publications

Recent research publications:

  • Machado TFG, Purg M, McMahon SA, Read BJ, Oehler V, Åqvist J, Gloster TM, da Silva RG. Dissecting the Mechanism of (R)-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry. Dec 2020, ACS catalysis 10, 15019-15032
  • Foltanyi F, Hawkins JE, Panovic I, Bird EJ, Gloster TMLancefield CS & Westwood NJ. Analysis of the product streams obtained on butanosolv pretreatment of draff. Oct 2020, Biomass and Bioenergy. 141, 105680.
  • Athukoralage JS, McQuarrie S, Grüschow S, Graham S, Gloster TM, White MF. Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage. 20 Jul 2020In : eLife. 919 p., e57627.
  • McMahon SA, Zhu W, Graham S, Rambo R, White MF, Gloster TM. Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate. Nat Commun. 2020 Jan 24;11(1):500.
  • Athukoralage JS, McMahon SA, Zhang C, Grueschow S, Graham S, Krupovic M, Whitaker RJ, Gloster TM, White MF. An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity. Nature. 2020 Jan;577(7791):572-575.
  • Machado TFG, Gloster TM, da Silva RG. Linear Eyring Plots Conceal a Change in the Rate-Limiting Step in an Enzyme Reaction. Biochemistry. 2018 Dec 11;57(49):6757-6761.
  • Artola M, Kuo CL, McMahon SA, Oehler V, Hansen T, van der Lienden M, He X, van den Elst H, Florea BI, Kermode AR, van der Marel GA, Gloster TM, Codee JDC, Overkleeft HS, Aerts JMFG. New Irreversible a-l-Iduronidase Inhibitors and Activity-Based Probes. Chemistry. 2018 Dec 17;24(71):19081-19088.
  • Ren W, Pengelly R, Farren-Dai M, Shamsi Kazem Abadi S, Oehler V, Akintola O, Draper J, Meanwell M, Chakladar S, Swiderek K, Moliner V, Britton R, Gloster TM, Bennet AJ. Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nat Commun. 2018 Aug 13;9(1):3243.
  • Liu TW, Zandberg WF, Gloster TM, Deng L, Murray KD, Shan X, Vocadlo DJ. Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing. Angew Chem Int Ed Engl. 2018 Jun 25;57(26):7644-7648.

Selected reviews:

  • TM Gloster. Exploitation of carbohydrate processing enzymes in biocatalysis, 2020, Current Opinion in Chemical Biology 55, 180-188.
  • LS Griffin, TM Gloster. The enzymatic degradation of heparan sulfate, 2017, Protein and peptide letters 24 (8), 710-722
  • TM Gloster. Advances in understanding glycosyltransferases from a structural perspective, 2014, Curr Opin Struct Biol 28,131-41.
  • TM Gloster. Development of inhibitors as research tools for carbohydrate-processing enzymes, 2012, Biochem Soc Trans, 40, 913-928.
  • TM Gloster & DJ Vocadlo. Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology, 2012, Nat Chem Biol, 8, 683-694.
  • TM Gloster & GJ Davies. Glycosidase inhibition: assessing mimicry of the transition state, 2010, Org Biomol Chem, 8, 305-320.

Selected research publications that highlights the type of work and techniques that are being used in the Gloster group:

  • TM Gloster, WF Zandberg, JE Heinonen, DL Shen, L Deng & DJ Vocadlo. Hijacking a biosynthetic pathway yields a potent glycosyltransferase inhibitor acting in cells, 2011, Nat Chem Biol, 7, 174-181.
  • TM Gloster, JP Turkenburg, JR Potts, B Henrissat & GJ Davies. Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora, 2008, Chem Biol, 15, 1058-1067.
  • TM Gloster, P Meloncelli, RV Stick, DL Zechel, A Vasella & GJ Davies. Glycosidase inhibition: an assessment of the binding of eighteen putative transition-state mimics, 2007, J Am Chem Soc, 129, 2345-2354.

 

A full and up-to-date publication list for Tracey can be found on Google Scholar.

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