Genome-wide molecular dating
Zuckerkandl and Pauling showed 50 years ago that molecular sequences are ‘documents of evolutionary history’. The composition of the molecular sequences of organisms living today has been passed on from ancestors from long ago. Unused segments get lost, new parts are added and small changes occur because replication is not error free. Whatever modifications have happened, they will have left traces in the molecular sequences.
In the advent of next generation sequencing technologies we have thousands of genomes available, however, we lack methods for genome-wide molecular dating. In this project, we will develop novel methods which will model not only mutations but also processes such as gene duplication, loss and transfer. We will also consider variation within species and devise methods that allow to use the genome-wide DNA sequences of multiple individuals per species to perform molecular dating.
Dr Rui Borges explains evolutionary processes with M&MsR
Mathematical and Statistical Aspects of Molecular Biology (MASAMB 2019) – Asger and Gergely win prizes
We attended MASAMB 2019 and a project group meeting at the European Bioinformatics Institute in Cambridge last week, and were quiet succesful with Asger Hobolth winning "Best Senior Talk" and Gergely Szollosi wining to organize the next MASAMB 2020. See you in...
Standard and APA published an article about contribution to the Baboon project https://www.derstandard.de/story/2000097256225/einer-oder-sechs-wie-der-pavian-einzuschaetzen-ist...
"Polymorphism-aware species trees with advanced mutation models, bootstrap and rate heterogeneity" by Dominik Schrempf, Bui Quang Minh, Arndt von Haeseler, and Carolin Kosiol. https://www.biorxiv.org/content/early/2018/12/01/483479