Scottish DNA Replication Network
The Scottish DNA Replication Network is an informal alliance of nine research groups from five leading Scottish universities with shared interests in the molecular, cell and structural biology of eukaryotic and archaeal chromosomal DNA replication. The group will hold its next meeting in St Andrews in May 2019.
Stuart MacNeill (University of St Andrews)
Network meeting 2019St Andrews, Wednesday 8th May 2019
Network meeting 2018St Andrews, Wednesday 30th May 2018
09.30 – 10.00 Tea and coffee
10.00 – 10.10 Opening remarks: Stuart MacNeill (University of St Andrews)
10.10 – 11.40 Session 1 (Chair: Anne Donaldson, University of Aberdeen)
10.10-10.25 Federico Tinarelli (University of Dundee): How replication licensing is regulated in G1 and what happens in Meier-Gorlin syndrome
10.25-10.40 Catarina Marques (University of Glasgow): Mapping DNA replication initiation reveals differences in origin usage between the related kinetoplastids, Trypanosoma brucei and Leishmania
10.40-10.55 Marcelo Santos da Silva (University of Glasgow): Transcription activity contributes to the activation of DNA replication origins above the minimum required to complete S phase in African trypanosomes
10.55-11.10 Laura Spagnolo (University of Glasgow): Structural studies of an archaeal MCM helicase
11.10-11.25 Martin Reijns (University of Edinburgh): Linking genome instability to innate immunity
11.25-11.40 Olga Murina (University of Edinburgh): Replication-associated damage at genomic ribonucleotides provides a therapeutic vulnerability to PARP inhibitors
12.00 – 13.20 Lunch
13.20 Group photograph
13.30 – 15.00 Session 2 (Chair: Richard McCulloch, University of Glasgow)
13.30-13.45 Tom Deegan (University of Dundee): Reconstituting DNA replication termination with purified proteins
13.45-14.00 Constance Alabert (University of Dundee): Restoration of chromatin-based information behind replication forks
14.00-14.15 Remi Sonneville (University of Dundee): Destroying the replisome during mitosis
14.15-14.30 Ananya Kar (University of Dundee): Post S-phase DNA synthesis
14.30-14.45 Javier Garzon (University of Aberdeen): Rif1 protects stalled forks from Dna2-mediated degradation.
14.45-15.00 Lotte Watts (University of Aberdeen): Roles of Rif1 splice variants
15.00 – 15.30 Tea and coffee
15.30 – 15.40 Frank Gunn-Moore (SULSA Deputy Director)
15.40 – 17.10 Session 3 (Chair: Laura Spagnolo, University of Glasgow)
15.40-15.55 Dmytro Kompaniiets (University of Glasgow): Structural studies of Okazaki fragments maturation.
15.55-16.10 Catherine Johnson (University of Aberdeen): Why does PCNA accumulation cause genome instability?
16.10-16.25 Lovely Devakumar (University of Aberdeen): Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
16.25-16.40 Vamsi Gali (University of Aberdeen): Identification of Elg1 interaction partners and effects on chromatin assembly.
16.40-16.55 Jonas Kondratavicius (University of St Andrews): Searching for Trypanosoma brucei DNA replication regulators
16.55-17.10 Jennifer Stortz (University of Glasgow) Trypanosoma brucei ATR: a protein kinase essential for parasite genome transmission, maintenance and host immune evasion
17.10 Informal discussion time
17.45 Walk to Forgans St Andrews for dinner
18.00 – 21.30 Dinner