Scottish DNA Replication Network

The Scottish DNA Replication Network is an informal alliance of nine research groups from five leading Scottish universities with shared interests in the molecular, cell and structural biology of eukaryotic and archaeal chromosomal DNA replication. The group will hold its next meeting in St Andrews on Wednesday May 30 2018.

Network members

Constance Alabert (Dundee) :
Julian Blow (Dundee)
Anne Donaldson (Aberdeen)
Takashi Kubota (Aberdeen)
Andrew Jackson (Edinburgh)
Karim Labib (Dundee)
Stuart MacNeill (St Andrews)
Richard McCulloch (Glasgow)
Laura Spagnolo (Glasgow)

Network coordinator

Stuart MacNeill (University of St Andrews)

Network meeting 2018

St Andrews, Wednesday 30th May 2018


The 2018 meeting of the Scottish DNA Replication Network will take place in Seminar Room 1 in the Medical & Biological Sciences Building (MBSB) at the University of St Andrews on Wednesday May 30 2018, starting at 10.00 (but with tea and coffee available from 09.30).


09.30 – 10.00 Tea and coffee

10.00 – 10.10 Opening remarks: Stuart MacNeill (University of St Andrews)


10.10 – 11.40 Session 1 (Chair: Anne Donaldson, University of Aberdeen)

10.10-10.25 Federico Tinarelli (University of Dundee): How replication licensing is regulated in G1 and what happens in Meier-Gorlin syndrome

10.25-10.40 Catarina Marques (University of Glasgow): Mapping DNA replication initiation reveals differences in origin usage between the related kinetoplastids, Trypanosoma brucei and Leishmania

10.40-10.55 Marcelo Santos da Silva (University of Glasgow): Transcription activity contributes to the activation of DNA replication origins above the minimum required to complete S phase in African trypanosomes

10.55-11.10 Laura Spagnolo (University of Glasgow): Structural studies of an archaeal MCM helicase

11.10-11.25 Martin Reijns (University of Edinburgh): Linking genome instability to innate immunity

11.25-11.40 Olga Murina (University of Edinburgh): Replication-associated damage at genomic ribonucleotides provides a therapeutic vulnerability to PARP inhibitors


12.00 – 13.20 Lunch

13.20 Group photograph


13.30 – 15.00 Session 2 (Chair: Richard McCulloch, University of Glasgow)

13.30-13.45 Tom Deegan (University of Dundee): Reconstituting DNA replication termination with purified proteins

13.45-14.00 Constance Alabert (University of Dundee):  Restoration of chromatin-based information behind replication forks

14.00-14.15 Remi Sonneville (University of Dundee): Destroying the replisome during mitosis

14.15-14.30 Ananya Kar (University of Dundee): Post S-phase DNA synthesis

14.30-14.45 Javier Garzon (University of Aberdeen): Rif1 protects stalled forks from Dna2-mediated degradation.

14.45-15.00 Lotte Watts (University of Aberdeen): Roles of Rif1 splice variants


15.00 – 15.30 Tea and coffee

15.30 – 15.40 Frank Gunn-Moore (SULSA Deputy Director)


15.40 – 17.10 Session 3 (Chair: Laura Spagnolo, University of Glasgow)

15.40-15.55 Dmytro Kompaniiets (University of Glasgow): Structural studies of Okazaki fragments maturation.

15.55-16.10 Catherine Johnson (University of Aberdeen): Why does PCNA accumulation cause genome instability?

16.10-16.25 Lovely Devakumar (University of Aberdeen): Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.

16.25-16.40 Vamsi Gali (University of Aberdeen): Identification of Elg1 interaction partners and effects on chromatin assembly.

16.40-16.55 Jonas Kondratavicius (University of St Andrews): Searching for Trypanosoma brucei DNA replication regulators

16.55-17.10 Jennifer Stortz (University of Glasgow) Trypanosoma brucei ATR: a protein kinase essential for parasite genome transmission, maintenance and host immune evasion


17.10 Informal discussion time

17.45 Walk to Forgans St Andrews for dinner

18.00 – 21.30  Dinner


The deadline for registration has now passed.


The Medical & Biological Sciences Building is located at the entrance to the University of St Andrews’ North Haugh campus, just 5 minutes from St Andrews bus station (with connections to Leuchars rail station) and is adjacent to the Petheram Bridge car park, with ample free public parking.


The network is sponsored by SULSA, the Scottish Universities Life Sciences Alliance, a strategic alliance between eight Scottish universities that aims to advance Scotland’s research and innovation in the life sciences, and by the Genetics Society.

Exhibiting sponsors

Financial support for the 2018 meeting is being provided by New England Biolabs, Cambridge BiosciencePCR Biosystems, Bioline, Thermo Fisher and Takara Bio.


For further information about the Scottish DNA Replication Network meeting, please email the network coordinator Dr Stuart MacNeill at

Banner photograph:
Glen Shiel, looking west
©2017 Steve Smart