Our lab is focussed on the molecular biology and evolution of proteins and pathways that manipulate nucleic acids, including helicases, nucleases and recombinases. We utilise a combination of structural, molecular and micro-biology, biochemistry and bioinformatics.We have particular interests in two main areas:
- the CRISPR-Cas system of antiviral defence – a fascinating aspect of prokaryotic molecular biology with many fundamental research questions and exciting applications in genome engineering and biotechnology.
2. DNA Repair pathways and proteins in humans and archaea. In particular, Nucleotide Excision Repair.
We have been funded by the BBSRC, Cancer Research UK, Association for International Cancer Research, Royal Society, EU framework VII and the Wellcome Trust.
Enquiries from potential Masters and PhD students are welcome at any time.
A short cv is available here: MFW 2-page cv 2016
Group photo from the 2013 CRISPR Conference in St Andrews: