- Our aim is to use the zoonotic malaria parasite Plasmodium knowlesi to improve our understanding of malaria pathophysiology.
- Malaria caused by Plasmodium falciparum is responsible for almost all of the estimated 584,000 malaria related deaths per year.
- Children in Sub-Saharan Africa are most at risk and despite intensive research we do not know why some individuals develop severe life threatening disease and others not.
- Rapid access to treatment is imperative to save lives but a more complete understanding of the disease process is important to develop augmentative therapies and vaccines.
- P. falciparum is adapted to the human host and there is no representative animal model system to bridge the gap between research findings and translation into human health benefit – P. knowlesi may help bridge this gap.