The Cox-Singh group works on zoonotic malaria caused by
Plasmodium knowlesi is a malaria parasite of Old World macaques that has entered the human population. A large focus of human cases of P. knowlesi malaria was discovered in the Kapit District of Sarawak, Malaysian Borneo. P. knowlesi was masquerading as the human host adapted malaria parasite P. malariae. New molecular tools were developed to properly identify P. knowlesi. With the new tools it soon became apparent that P. knowlesi malaria was wide-spread, could cause severe and fatal infections. Similar to Plasmodium falciparum, P. knowlesi could reach very high parasitaemia in those infected. Our goal is to discover why some people develop high parasitaemia and severe disease and others not.