Abstract Malaria is caused by member species of the genus Plasmodium. Plasmodium species are eukaryotic parasites that require two hosts to complete their complex lifecycle:
Malaria is caused by member species of the genus Plasmodium. Plasmodium species are eukaryotic parasites that require two hosts to complete their complex lifecycle: A vertebrate host for asexual reproduction and amplification and a female Anopheline mosquito host for sexual reproduction. There are over 200 Plasmodium species that co-exist with and are restricted to various bird, rodent, non-human primate and reptile species and their Anopheline partners. A few Plasmodium species have adapted to the human host but infection most often results in the signs and symptoms of malaria. Malaria, per se, is the result of asexual reproduction and cycling in the red blood cells of infected individuals. At the dawn of the new millennium a large entry of Plasmodium knowlesi, a parasite of old world monkeys, was discovered in the human population in Malaysian Borneo. Zoonotic malaria, caused by P. knowlesi, is currently responsible for most cases of malaria in Malaysia and is widespread in other human populations across Southeast Asia. What were the drivers for this cross host-species emergence? Were we observing a single crossover event and clonal expansion? How do we control zoonotic malaria transmission? What are the clinical features of disease? The questions were many, difficult to prioritise and on-going – some of the answers will be presented.
Janet Cox-Singh is a research scientist in the School of Medicine here at the University of St Andrews. Here she has her own lab that focuses on using the zoonotic malaria parasite Plasmodium knowlesi to improve our understanding of malaria pathophysiology.
If you would like to talk to Janet, please contact V Anne Smith.
(Tuesday) 1:00 pm - 2:00 pm
Ellen Garland & Christian Rutzecg5@st-andrews.ac.uk, email@example.com Dyers Brae, University of St Andrews, St Andrews, Fife, KY16 9TH, UK