We are interested in how shape and form arise during animal development. During morphogenesis, cells interpret complex information and react accordingly to shape tissues and organs. Here, many cell behaviours, such as cell migration and cell shape changes, work together. Despite recent progress, it still remains mysterious how all these behaviours are regulated and coordinated.
To gain insights into the regulation and coordination of cell behaviours, we study the morphogenesis of the adult abdominal epidermis of Drosophila. Employing a combination of in vivo 4D microscopy and sophisticated genetics, we observe and quantify all cell behaviours after experimental manipulation of the system. This allows us to gain a deeper understanding of morphogenetic processes and the underlying cell behaviours. These insights will be of widespread relevance, since the (mis-) regulation of cell behaviour is also fundamental to wound repair and numerous diseases, including cancer.
Dr. Marcus Bischoff
Biomolecular Sciences Building
University of St Andrews
Tel: 01334 467199