Biology Online Module Handbook

BL4216 Structure based Drug Discovery

(BL4216 online module handbook version 21)

cover image

image: N1 neuraminidase in complex with oseltamivir (from http://www.rcsb.org/pdb/explore/explore.do?structureId=2hu4)

The process of developing a new drug from conception to the clinic takes on average 15 years and costs over $800M. There are now many examples of drugs developed based on a knowledge of the three dimensional structure of the target, and all major pharmaceutical companies have structural biology as part of their core drug discovery programmes. Many drugs currently used to combat AIDS were developed from a detailed knowledge of key HIV proteins, as were the two drugs used for influenza. Most major pharmaceutical companies are targeting kinases in the search for new cancer therapies, with international efforts focusing on producing structural details of huge numbers of human kinases.This module will examine case studies of drugs that have been developed with the aid of structure-based methods.*

Credits: 15*

Semester: 1

Module Organiser
Dr Tracey Gloster
tmg@st-andrews.ac.uk
01334 467245
Pre-requisite Modules:
PERMISSION OF BIOLOGY HONOURS ADVISER REQUIRED*
Anti-requisite Modules:
None*
Post-requisite Modules:
*
Additional Module Information:
Please check MMS regularly for additional module information


Biology Teaching Office:
Room 1.17, Biomolecular Sciences Building, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST

Email: bioteach@st-andrews.ac.uk      Tel: 01334  463602

BL4216: Timetable

Legend (not all modules have every event type):
lecture
tutorial
workshop
practical
other

Semester 1: Week 1

DATE & TIMEVENUESTAFFEVENT
Wednesday
20-09-2017
09:00 to 10:00
Bute Building
Lecture theatre A
Dr Tracey Gloster

Lecture L1: Module Overview
2017-8_BL4216_L1
Thursday
21-09-2017
10:00 to 11:00
Physics Building
Room 301
Dr Tracey Gloster

Lecture L2: Overview of drug discovery
2017-8_BL4216_L2

Semester 1: Week 2

DATE & TIMEVENUESTAFFEVENT
Tuesday
26-09-2017
10:00 to 11:00
Physics Building
Room 301
Dr Tracey Gloster

Lecture L3: Structure-based drug discovery
2017-8_BL4216_L3
Thursday
28-09-2017
10:00 to 11:00
Physics Building
Room 301
DouglasThomson
Dr Tracey Gloster
Lecture L4: Someone who has done it!
2017-8_BL4216_L4

Semester 1: Week 3

DATE & TIMEVENUESTAFFEVENT
Tuesday
03-10-2017
10:00 to 11:00
Physics Building
Room 301
Dr Ewan Chirnside
Dr Tracey Gloster
Lecture L5: Intellectual Property
2017-8_BL4216_L5
Thursday
05-10-2017
10:00 to 11:00
Physics Building
Room 301
Dr Tracey Gloster

Workshop W1: Pymol workshop
2017-8_BL4216_W1
Friday
06-10-2017
14:00 to 15:00
Medical and Biological Sciences Building
Seminar room 2
Prof Garry Taylor
Dr Tracey Gloster
Lecture L6: Case Study: HN from Paramyxoviruses
2017-8_BL4216_L6

Semester 1: Week 4

DATE & TIMEVENUESTAFFEVENT
Wednesday
11-10-2017
09:00 to 10:00
Bute Building
Lecture theatre A
NicolaMarchant
Dr Tracey Gloster
Lecture L7: Bioethics
2017-8_BL4216_L7

Semester 1: Week 5

DATE & TIMEVENUESTAFFEVENT
Thursday
19-10-2017
10:00 to 13:00
Bute Building
Lecture theatre D
Dr Tracey Gloster
Dr Jacqueline Nairn
Other O1: Student Presentation 1 - The Disease
2017-8_BL4216_O1

Semester 1: Week 7

DATE & TIMEVENUESTAFFEVENT
Thursday
02-11-2017
10:00 to 13:00
Bute Building
Lecture theatre D
Dr Tracey Gloster
Dr Jacqueline Nairn
Other O2: Student Presentation 2 - The Target and Strategy for Drug Discovery
2017-8_BL4216_O2

Semester 1: Week 9

DATE & TIMEVENUESTAFFEVENT
Tuesday
14-11-2017
10:00 to 13:00
Medical and Biological Sciences Building
Seminar room 1
Dr Tracey Gloster
Dr Jacqueline Nairn
Other O3: Student Presentation 3 - Complete Pitch
2017-8_BL4216_O3

Semester 1: Week 11

DATE & TIMEVENUESTAFFEVENT
Thursday
30-11-2017
10:00 to 12:00
Bute Building
Lecture theatre D
Dr Tracey Gloster

Workshop W2: Synoptic Exam Practice
2017-8_BL4216_W2
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL4216: Reading List

Click for BL4216 reading list

BL4216: Assessment

1.5-hour Written Examination = 40%, Coursework = 60%*

Assessment:
Essay
Due by:
12/10/2017 16:00
Feedback due by:
02/11/2017 16:00
Type:
Single Upload
Weight:
33.33%
Assessment:
Presentation 1 - Disease
Due by:
19/10/2017 10:00
Feedback due by:
09/11/2017 10:00
Type:
Single Upload
Weight:
0%
Assessment:
Presentation 2 - Target
Due by:
02/11/2017 10:00
Feedback due by:
23/11/2017 10:00
Type:
Single Upload
Weight:
33.33%
Assessment:
Presentation 3 - Pitch
Due by:
14/11/2017 10:00
Feedback due by:
05/12/2017 10:00
Type:
Single Upload
Weight:
33.33%

(MMS assessment data cached: 20 September 2017 22:20:10.)


The following related information applies to all Biology modules:

School of Biology Marking Criteria: See School of Biology Undergraduate Handbook
Late submission of continuous assessment work:

All late submissions of coursework that do not require electronic submission should be made via the late submissions box in the Biomolecular Science Building (beside the Teaching Office)
Exam details: See School of Biology Undergraduate Handbook
Exam timetable: see http://www.st-andrews.ac.uk/students/academic/examinations/examtimetablescurrent/
Expected attendance: See School of Biology Undergraduate Handbook for detailed attendance requirements.
Good Academic Practice & Avoiding Academic Misconduct: See School of Biology Undergraduate Handbook
University Student Handbook: University Student Handbook
School and University regulations in the School and University Undergraduate Handbook relating to absence reporting, penalties and rules for late submission of work, extensions for coursework, return of coursework, S-coding, good academic practice and Academic Alerts.: School of Biology Undergraduate Handbook University Student Handbook
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Who to ask

(Information in this section applies to all Biology Modules)

Questions about different aspects of the module should be directed to different people:

Questions about Contact
General teaching matters Biology Teaching Office ( bioteach@st-andrews.ac.uk )
Rescheduled or cancelled events Check your University email
Lecture or practical content The lecturer who presented the material
Completing assessed practical assignments The lecturer who set the assignment
Completing assessments Module Organiser (Dr Tracey Gloster tmg@st-andrews.ac.uk)
Marking on continuous assessment The Demonstrator or Module Organiser (Dr Tracey Gloster tmg@st-andrews.ac.uk)
Marking on exams Module Organiser (Dr Tracey Gloster tmg@st-andrews.ac.uk)
Rearranging practical days Grant Brown
Absence and/or extensions Module Organiser (Dr Tracey Gloster tmg@st-andrews.ac.uk) and the Biology Teaching Office ( bioteach@st-andrews.ac.uk )

Difficulties with academic progress which impact more than one module:

Year Coordinator

See School of Biology Undergraduate student handbook for list: http://biology.st-andrews.ac.uk/documents/UndergraduateHandbook.pdf

Overall performance, progress or future directions:

Advisor of Studies

Disability:

Disability Coordinator (Dr Jacqueline Nairn jn37@st-andrews.ac.uk)

Biology Teaching Office:

Room 1.17, Biomolecular Sciences Building, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST

Email: bioteach@st-andrews.ac.uk

Tel: 01334 463602

BL4216: Contributing Staff

Dr Tracey Gloster

Dr Tracey Gloster
(Module Organiser)

Wellcome Trust Research Fellowtmg@st-andrews.ac.uk
Dr Ewan ChirnsideDirector of Knowledge Transfer Centreec36@st-andrews.ac.uk
Dr Tracey GlosterDr Tracey Gloster
(Module Organiser)
Wellcome Trust Research Fellowtmg@st-andrews.ac.uk
Dr Jacqueline NairnSenior Lecturer (Education Focused)jn37@st-andrews.ac.uk
Prof Garry TaylorProf Garry TaylorProfessor of Molecular Biophysicsglt2@st-andrews.ac.uk
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL4216: Learning Outcomes

Students completing module BL4216 successfully should be able to:

  • Recognise and describe the steps involved in developing a new drug and getting the new drug to the market
  • Appreciate the importance of Intellectual Property (IP) and issues such as protecting inventions through patents
  • Assess drug design strategies
  • Identify a disease in need of drug development
  • Select a drug design strategy for an identified disease and develop a marketing strategy for this novel drug
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL4216: Acquired Skills

Practical Skills

  • Database interogation
  • Molecular viewer software

Transferable Skills

  • Group discussion - participating
  • Long group presentation on project idea (>15 min)
  • Group pamphlet aimed at general audience
  • Handout (for presentation or poster)
  • Long essay (>2000 words)
  • Finding information on the web
  • Finding literature
  • Searching databases
  • Sourcing figures/tables
  • Peer assessment
  • Organising group work
  • Working in pairs/small groups
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Policies

(Information in this section applies to all Biology Modules)