Biology Online Module Handbook

BL3303 Membranes and Cell Communication

(BL3303 online module handbook version 31)

cover image

image: Cytonemes (green) and Hedgehog signalling activity reporter (red) in Drosophila wing imaginal disc.

This module looks at the various ways in which cells communicate with each other. Cell signalling not only involves the creation and reception of signals but also the mechanisms by which signals are transported across biological membranes. We will therefore consider the central role that biological membranes play in the regulation of the movement of molecules between different extracellular, intracellular and transcellular compartments. Also protein sorting and membrane trafficking will be studied. Using various examples of cell communication, the module will discuss both the molecular and the organismal implications of cell signalling. Topics covered include:(i) Lipids; (ii) Protein targeting and sorting; (iii) Membrane trafficking and transport; (iv) Wnt, Notch and Hedgehog signalling; (v) Plant cell signalling; (vi) Hippo signalling (vii) Ubiquitylation and SUMOylation.*

Credits: 20*

Semester: 2

Module Organiser
Dr Marcus Bischoff
mb273@st-andrews.ac.uk
01334 467199
Pre-requisite Modules:
Before taking this module you must pass BL2301 and ( pass BL2305 or pass BL2306 or pass BL2309 )*
Anti-requisite Modules:
*
Post-requisite Modules:
*
Additional Module Information:
Please check MMS regularly for additional module information


Biology Teaching Office:
The Biology Hive, New Technology Centre, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SR

Email: bioteach@st-andrews.ac.uk      Tel: 01334  463602

BL3303: Timetable

Legend (not all modules have every event type):
lecture
tutorial
workshop
practical
other

Semester 2: Week 1

DATE & TIMEVENUESTAFFEVENT
Monday
28-01-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith
Dr Marcus Bischoff
Lecture L1: Lipids I
2018-9_BL3303_L1
Tuesday
29-01-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith

Lecture L2: Lipids II
2018-9_BL3303_L2
Wednesday
30-01-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr David J Hughes

Lecture L3: Practical 1 - Introduction
2018-9_BL3303_L3
Thursday
31-01-2019
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr David J Hughes

Practical P1: Practical 1 - Cell fractionation
2018-9_BL3303_P1
Friday
01-02-2019
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr David J Hughes

Practical P2: Practical 1 - Cell fractionation
2018-9_BL3303_P2

Semester 2: Week 2

DATE & TIMEVENUESTAFFEVENT
Tuesday
05-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr David J Hughes

Lecture L4: Practical 1 - Feedback/discussion
2018-9_BL3303_L4
Wednesday
06-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith

Tutorial T1: Tutorial 1 - Reading of a scientific article
2018-9_BL3303_T1

Semester 2: Week 3

DATE & TIMEVENUESTAFFEVENT
Monday
11-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith

Lecture L5: G protein-coupled receptors
2018-9_BL3303_L5
Tuesday
12-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith

Tutorial T2: Tutorial 2 - Summary of a scientific article
2018-9_BL3303_T2

Semester 2: Week 4

DATE & TIMEVENUESTAFFEVENT
Monday
18-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L6: The secretory pathway & protein sorting
2018-9_BL3303_L6
Tuesday
19-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L7: Molecular mechanisms of regulated exocytosis
2018-9_BL3303_L7
Wednesday
20-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L8: Key experiments in membrane trafficking
2018-9_BL3303_L8

Semester 2: Week 5

DATE & TIMEVENUESTAFFEVENT
Monday
25-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L9: Wnt signalling
2018-9_BL3303_L9
Tuesday
26-02-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L10: Hedgehog signalling I
2018-9_BL3303_L10
Wednesday
27-02-2019
09:00 to 10:00
Biomedical Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L11: Practical 2 - Introduction
2018-9_BL3303_L11
Thursday
28-02-2019
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr Marcus Bischoff

Practical P3: Practical 2 - Imaginal disc staining
2018-9_BL3303_P3
Friday
01-03-2019
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr Marcus Bischoff

Practical P4: Practical 2 - Imaginal disc staining
2018-9_BL3303_P4

Semester 2: Week 6

DATE & TIMEVENUESTAFFEVENT
Monday
04-03-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L12: Hedgehog signalling II
2018-9_BL3303_L12
Tuesday
05-03-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L13: Notch and Integrin signalling
2018-9_BL3303_L13
Wednesday
06-03-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L14: Ion channels and their gating
2018-9_BL3303_L14

Semester 2: Week 7

DATE & TIMEVENUESTAFFEVENT
Monday
11-03-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L15: Signalling pathways in GLUT4 trafficking
2018-9_BL3303_L15
Tuesday
12-03-2019
09:00 to 10:00
Biomedical Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L16: Ras-proteins
2018-9_BL3303_L16
Wednesday
13-03-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L17: Desensitization of receptors, ubiquitination
2018-9_BL3303_L17

Reading Week: 16-Mar-2019 to 31-Mar-2019

Semester 2: Week 8

DATE & TIMEVENUESTAFFEVENT
Monday
01-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Frank Gunn-Moore

Lecture L18: The discovery of Willin
2018-9_BL3303_L18
Tuesday
02-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Frank Gunn-Moore

Lecture L19: Hippo signalling
2018-9_BL3303_L19
Wednesday
03-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Frank Gunn-Moore

Tutorial T3: Tutorial 3 - Reading of papers on Hippo signalling
2018-9_BL3303_T3

Semester 2: Week 9

DATE & TIMEVENUESTAFFEVENT
Monday
08-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Paul Reynolds

Lecture L20: The Hippo signalling pathway and cancer
2018-9_BL3303_L20
Tuesday
09-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Samantha Pitt

Lecture L21: An introduction into cellular Calcium signalling
2018-9_BL3303_L21
Wednesday
10-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Alison Roberts

Lecture L22: Practical 3 - Introduction
2018-9_BL3303_L22
Thursday
11-04-2019
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr Alison Roberts

Practical P5: Practical 3 - Western blotting
2018-9_BL3303_P5
Friday
12-04-2019
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr Alison Roberts

Practical P6: Practical 3 - Western blotting
2018-9_BL3303_P6

Semester 2: Week 10

DATE & TIMEVENUESTAFFEVENT
Monday
15-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Alison Roberts

Lecture L23: Plant transport systems
2018-9_BL3303_L23
Tuesday
16-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Alison Roberts

Lecture L24: Molecular trafficking in plants
2018-9_BL3303_L24
Wednesday
17-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Jens Tilsner

Lecture L25: RNA signalling in plants
2018-9_BL3303_L25

Semester 2: Week 11

DATE & TIMEVENUESTAFFEVENT
Monday
22-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr David J Hughes

Lecture L26: The SUMO signal
2018-9_BL3303_L26
Wednesday
24-04-2019
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Tutorial T4: Tutorial 4 - Deductive questions
2018-9_BL3303_T4
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL3303: Assessment

3-hour Written Examination = 66%, Coursework = 34%*

Assessment:
Summary
Due by:
22/02/2019 14:00
Feedback due by:
18/03/2019 14:00
Type:
Turnitin
Weight:
41.2%
Assessment:
Report Practical 2
Due by:
15/03/2019 14:00
Feedback due by:
05/04/2019 14:00
Type:
Turnitin
Weight:
58.8%

(MMS assessment data cached: 17 April 2019 22:20:21.)


The following related information applies to all Biology modules:

School of Biology Marking Criteria: See School of Biology Undergraduate Handbook
Late submission of continuous assessment work:

All late submissions of coursework that do not require electronic submission should be made via the late submissions box in the Biomolecular Science Building (beside the Teaching Office)
Exam details: See School of Biology Undergraduate Handbook
Exam timetable: see http://www.st-andrews.ac.uk/students/academic/examinations/examtimetablescurrent/
Expected attendance: See School of Biology Undergraduate Handbook for detailed attendance requirements.
Good Academic Practice & Avoiding Academic Misconduct: See School of Biology Undergraduate Handbook
University Student Handbook: University Student Handbook
School and University regulations in the School and University Undergraduate Handbook relating to absence reporting, penalties and rules for late submission of work, extensions for coursework, return of coursework, S-coding, good academic practice and Academic Alerts.: School of Biology Undergraduate Handbook University Student Handbook
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Who to ask

(Information in this section applies to all Biology Modules)

Questions about different aspects of the module should be directed to different people:

Questions about Contact
General teaching matters Biology Teaching Office ( bioteach@st-andrews.ac.uk )
Rescheduled or cancelled events Check your University email
Lecture or practical content The lecturer who presented the material
Completing assessed practical assignments The lecturer who set the assignment
Completing assessments Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk)
Marking on continuous assessment The Demonstrator or Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk)
Marking on exams Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk)
Rearranging practical days Grant Brown
Absence and/or extensions Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk) and the Biology Teaching Office ( bioteach@st-andrews.ac.uk )

Difficulties with academic progress which impact more than one module:

Year Coordinator

See School of Biology Undergraduate student handbook for list: http://biology.st-andrews.ac.uk/documents/UndergraduateHandbook.pdf

Overall performance, progress or future directions:

Advisor of Studies

Disability:

Disability Coordinator (Dr Jacqueline Nairn jn37@st-andrews.ac.uk)

For advice and support on any issue e.g. academic, financial, international, personal or health matters, or if you are unsure of who to go to for help:

Advice & Support Centre

Address: 79 North Street, St Andrews

Email: theasc@st-andrews.ac.uk

Web: https://www.standrews.ac.uk/ask-a-question/

Tel: 01334 462020

University assistance with urgent matters out of office hours:

Tel: 01334 476161

Web: https://www.st-andrews.ac.uk/students/advice/counselling/incrisis/

Biology Teaching Office:

We are happy to hear from you about teaching matters. The School of Biology Teaching Office is open Monday to Friday 09.00 - 13.00 and 14.00 - 17.00. School of Biology staff will respond to your emails during these hours. Our team will provide a response to you within three working days.

Biology Teaching Office, The Biology Hive, New Technology Centre, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SR

Email: bioteach@st-andrews.ac.uk

Tel: 01334 463602/3566

BL3303: Contributing Staff

Dr Marcus Bischoff

Dr Marcus Bischoff
(Module Organiser)

Lecturermb273@st-andrews.ac.uk
Dr Marcus BischoffDr Marcus Bischoff
(Module Organiser)
Lecturermb273@st-andrews.ac.uk
Prof Frank Gunn-MooreProf Frank Gunn-MooreProfessor of Molecular Neurobiology, Head of School fjg1@st-andrews.ac.uk
Dr David J HughesDr David J HughesLecturerdjh25@st-andrews.ac.uk
Dr Samantha PittDr Samantha PittRoyal Society of Edinburgh Biomedical Fellowsjp24@st-andrews.ac.uk
Dr Gerald PrescottSenior Lecturergrp2@st-andrews.ac.uk
Dr Paul ReynoldsDr Paul ReynoldsLecturer and Director of Postgraduate Studiespar10@st-andrews.ac.uk
Dr Alison RobertsHonorary Readerar255@st-andrews.ac.uk
Prof Terry SmithProf Terry SmithProfessortks1@st-andrews.ac.uk
Dr Jens TilsnerDr Jens TilsnerLecturerjt58@st-andrews.ac.uk
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL3303: Learning Outcomes

The objective of this module is to provide insights into how cells communicate with each other, emphasising properties of biological membranes, membrane trafficking and cell signalling. Also to facilitate the development of essential scientific skills.

Students completing module BL3303 successfully should be able to:

  • Acquire an understanding of the biology of biological membranes, protein sorting and membrane trafficking
  • Gain insights into the mechanisms underlying cell signalling and signal transduction
  • Find and critically read and evaluate literature
  • Produce a summary of a scientific paper and a practical report
  • Produce a figure of the results of a practical
  • Work in small teams in a lab-based context
  • Plan work in order to meet deadlines
  • Understand the principles that underlie cell communication
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL3303: Acquired Skills

Practical Skills

  • Compound Microscopy
  • Fixing and preserving specimens
  • Image processing
  • Pipetting
  • Stereomicroscopy

Transferable Skills

  • "Full" practical write-up (Intro, Methods, Results, Discussion)
  • Completing a research paper from which sections have been removed
  • Problem-solving questions
  • Data presentation
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Policies

(Information in this section applies to all Biology Modules)