Biology Online Module Handbook

BL3303 Membranes and Cell Communication

(BL3303 online module handbook version 15)

cover image

image: Cytonemes (green) and Hedgehog signalling activity reporter (red) in Drosophila wing imaginal disc.

This module looks at the various ways in which cells communicate with each other. Cell signalling not only involves the creation and reception of signals but also the mechanisms by which signals are transported across biological membranes. We will therefore consider the central role that biological membranes play in the regulation of the movement of molecules between different extracellular, intracellular and transcellular compartments. Also protein sorting and membrane trafficking will be studied. Using various examples of cell communication, the module will discuss both the molecular and the organismal implications of cell signalling. Topics covered include:(i) Lipids; (ii) Protein targeting and sorting; (iii) Membrane trafficking and transport; (iv) Wnt, Notch and Hedgehog signalling; (v) Plant cell signalling; (vi) Hippo signalling (vii) Ubiquitylation and SUMOylation.*

Credits: 20*

Semester: 2

Module Organiser
Dr Marcus Bischoff
mb273@st-andrews.ac.uk
01334 467199
Pre-requisite Modules:
BEFORE TAKING THIS MODULE YOU MUST PASS BL2301 AND ( PASS BL2305 OR PASS BL2306 OR PASS BL2309 )*
Anti-requisite Modules:
None*
Post-requisite Modules:
BL4224, BL5420*
Additional Module Information:
Please check MMS regularly for additional module information


Biology Teaching Office:
The Biology Hive, New Technology Centre, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SR

Email: bioteach@st-andrews.ac.uk      Tel: 01334  463602

BL3303: Timetable

Legend (not all modules have every event type):
lecture
tutorial
workshop
practical
other

Semester 2: Week 1

DATE & TIMEVENUESTAFFEVENT
Monday
29-01-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith
Dr Marcus Bischoff
Lecture L1: Lipids I
2017-8_BL3303_L1
Tuesday
30-01-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith

Lecture L2: Lipids II
2017-8_BL3303_L2
Wednesday
31-01-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith
Dr David J Hughes
Tutorial T1: Tutorial 1 Reading a scientific article & Practical 1 introduction
2017-8_BL3303_T1
Thursday
01-02-2018
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr David J Hughes

Practical P1: Cell fractionation
2017-8_BL3303_P1
Friday
02-02-2018
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr David J Hughes

Practical P2: Cell fractionation
2017-8_BL3303_P2

Semester 2: Week 2

DATE & TIMEVENUESTAFFEVENT
Tuesday
06-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr David J Hughes

Lecture L3: Practical 1 feedback - discussion
2017-8_BL3303_L3
Wednesday
07-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Terry Smith

Tutorial T2: Tutorial 2 Summary of a scientific article
2017-8_BL3303_T2

Semester 2: Week 3

DATE & TIMEVENUESTAFFEVENT
Monday
12-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Christos Pliotas

Lecture L4: G-protein-coupled receptors 1
2017-8_BL3303_L4
Tuesday
13-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Christos Pliotas

Lecture L5: G-protein-coupled receptors 2
2017-8_BL3303_L5

Semester 2: Week 4

DATE & TIMEVENUESTAFFEVENT
Monday
19-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L6: The scretory pathway & protein sorting
2017-8_BL3303_L6
Tuesday
20-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L7: Molecular mechanisms of regulated exocytosis
2017-8_BL3303_L7
Wednesday
21-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L8: Key experiments in membrane trafficking
2017-8_BL3303_L8

Semester 2: Week 5

DATE & TIMEVENUESTAFFEVENT
Monday
26-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L9: Ion channels and their gating
2017-8_BL3303_L9
Tuesday
27-02-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L10: Wnt signalling
2017-8_BL3303_L10

Semester 2: Week 6

DATE & TIMEVENUESTAFFEVENT
Monday
05-03-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L11: Signalling pathways in GLUT4 trafficking
2017-8_BL3303_L11
Tuesday
06-03-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L12: Ras-proteins
2017-8_BL3303_L12
Wednesday
07-03-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Gerald Prescott

Lecture L13: Desensitization of receptors, ubiquitination
2017-8_BL3303_L13

Semester 2: Week 7

DATE & TIMEVENUESTAFFEVENT
Monday
12-03-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L14: Hedgehog signalling 1
2017-8_BL3303_L14
Tuesday
13-03-2018
00:00 to 00:00
Biomedical Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L15: Hedgehog signalling 2
2017-8_BL3303_L15
Wednesday
14-03-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L16: Integrin signalling & ECM
2017-8_BL3303_L16

Reading Week: 17-Mar-2018 to 01-Apr-2018

Semester 2: Week 8

DATE & TIMEVENUESTAFFEVENT
Monday
02-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Frank Gunn-Moore

Lecture L17: The discovery of Willin
2017-8_BL3303_L17
Tuesday
03-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Frank Gunn-Moore

Lecture L18: Hippo signalling
2017-8_BL3303_L18
Wednesday
04-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Prof Frank Gunn-Moore

Tutorial T3: Tutorial 3 Reading of papers on Hippo signalling
2017-8_BL3303_T3

Semester 2: Week 9

DATE & TIMEVENUESTAFFEVENT
Monday
09-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Paul Reynolds

Lecture L19: The Hippo signalling pathway and cancer
2017-8_BL3303_L19
Wednesday
11-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Lecture L20: Practical 2 introduction
2017-8_BL3303_L20
Thursday
12-04-2018
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr Marcus Bischoff

Practical P3: Practical 2 €" Imaginal disc staining
2017-8_BL3303_P3
Friday
13-04-2018
09:00 to 17:00
Purdie Building
Honours lab, level 3
Dr Marcus Bischoff

Practical P4: Practical 2 €" Imaginal disc staining
2017-8_BL3303_P4

Semester 2: Week 10

DATE & TIMEVENUESTAFFEVENT
Monday
16-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Alison Roberts

Lecture L21: Plant transport systems
2017-8_BL3303_L21
Tuesday
17-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Alison Roberts

Lecture L22: Molecular trafficking in plants
2017-8_BL3303_L22
Wednesday
18-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Jens Tilsner

Lecture L23: RNA signalling in plants
2017-8_BL3303_L23

Semester 2: Week 11

DATE & TIMEVENUESTAFFEVENT
Monday
23-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr David J Hughes

Lecture L24: The SUMO signal
2017-8_BL3303_L24
Tuesday
24-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Samantha Pitt

Lecture L25: An introduction into cellular Calcium signalling
2017-8_BL3303_L25
Wednesday
25-04-2018
09:00 to 10:00
Biomolecular Sciences Building
Lecture Theatre
Dr Marcus Bischoff

Tutorial T4: Tutorial 4 Deductive questions
2017-8_BL3303_T4
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL3303: Reading List

Click for BL3303 reading list

BL3303: Assessment

3-hour Written Examination = 66%, Coursework = 34%*

Assessment:
Summary
Due by:
23/02/2018 14:00
Feedback due by:
16/03/2018 14:00
Type:
Turnitin
Weight:
41.2%
Assessment:
Report Practical 2
Due by:
27/04/2018 14:00
Feedback due by:
18/05/2018 14:00
Type:
Turnitin
Weight:
58.8%

(MMS assessment data cached: 28 March 2018 22:20:20.)


The following related information applies to all Biology modules:

School of Biology Marking Criteria: See School of Biology Undergraduate Handbook
Late submission of continuous assessment work:

All late submissions of coursework that do not require electronic submission should be made via the late submissions box in the Biomolecular Science Building (beside the Teaching Office)
Exam details: See School of Biology Undergraduate Handbook
Exam timetable: see http://www.st-andrews.ac.uk/students/academic/examinations/examtimetablescurrent/
Expected attendance: See School of Biology Undergraduate Handbook for detailed attendance requirements.
Good Academic Practice & Avoiding Academic Misconduct: See School of Biology Undergraduate Handbook
University Student Handbook: University Student Handbook
School and University regulations in the School and University Undergraduate Handbook relating to absence reporting, penalties and rules for late submission of work, extensions for coursework, return of coursework, S-coding, good academic practice and Academic Alerts.: School of Biology Undergraduate Handbook University Student Handbook
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Who to ask

(Information in this section applies to all Biology Modules)

Questions about different aspects of the module should be directed to different people:

Questions about Contact
General teaching matters Biology Teaching Office ( bioteach@st-andrews.ac.uk )
Rescheduled or cancelled events Check your University email
Lecture or practical content The lecturer who presented the material
Completing assessed practical assignments The lecturer who set the assignment
Completing assessments Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk)
Marking on continuous assessment The Demonstrator or Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk)
Marking on exams Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk)
Rearranging practical days Grant Brown
Absence and/or extensions Module Organiser (Dr Marcus Bischoff mb273@st-andrews.ac.uk) and the Biology Teaching Office ( bioteach@st-andrews.ac.uk )

Difficulties with academic progress which impact more than one module:

Year Coordinator

See School of Biology Undergraduate student handbook for list: http://biology.st-andrews.ac.uk/documents/UndergraduateHandbook.pdf

Overall performance, progress or future directions:

Advisor of Studies

Disability:

Disability Coordinator (Dr Jacqueline Nairn jn37@st-andrews.ac.uk)

Biology Teaching Office:

The Biology Hive, New Technology Centre, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SR

Email: bioteach@st-andrews.ac.uk

Tel: 01334 463602

BL3303: Contributing Staff

Dr Marcus Bischoff

Dr Marcus Bischoff
(Module Organiser)

Lecturermb273@st-andrews.ac.uk
Dr Marcus BischoffDr Marcus Bischoff
(Module Organiser)
Lecturermb273@st-andrews.ac.uk
Prof Frank Gunn-MooreProf Frank Gunn-MooreProfessor of Molecular Neurobiology
Director of Research
fjg1@st-andrews.ac.uk
Dr David J HughesDr David J HughesResearch Fellowdjh25@st-andrews.ac.uk
Dr Samantha PittDr Samantha PittRoyal Society of Edinburgh Biomedical Fellowsjp24@st-andrews.ac.uk
Dr Christos PliotasDr Christos PliotasRoyal Society of Edinburgh Research Fellowcp39@st-andrews.ac.uk
Dr Gerald PrescottDirector of Teachinggrp2@st-andrews.ac.uk
Dr Paul ReynoldsDr Paul ReynoldsLecturer and Director of Postgraduate Studiespar10@st-andrews.ac.uk
Dr Alison RobertsHonorary Readerar255@st-andrews.ac.uk
Prof Terry SmithProf Terry SmithProfessortks1@st-andrews.ac.uk
Dr Jens TilsnerDr Jens TilsnerLecturerjt58@st-andrews.ac.uk
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL3303: Learning Outcomes

The objective of this module is to provide insights into how cells communicate with each other, emphasising properties of biological membranes, membrane trafficking and cell signalling. Also to facilitate the development of essential scientific skills.

Students completing module BL3303 successfully should be able to:

  • Acquire an understanding of the biology of biological membranes, protein sorting and membrane trafficking
  • Gain insights into the mechanisms underlying cell signalling and signal transduction
  • Find and critically read and evaluate literature
  • Produce a summary of a scientific paper and a practical report
  • Produce a figure of the results of a practical
  • Work in small teams in a lab-based context
  • Plan work in order to meet deadlines
  • Understand the principles that underlie cell communication
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

BL3303: Acquired Skills

Practical Skills

  • Compound Microscopy
  • Fixing and preserving specimens
  • Image processing
  • Pipetting
  • Stereomicroscopy

Transferable Skills

  • "Full" practical write-up (Intro, Methods, Results, Discussion)
  • Completing a research paper from which sections have been removed
  • Problem-solving questions
  • Data presentation
Data Sources: information in this online module handbook is gathered from several sources.
Small footnote marks beside content, or by section titles indicate the source.
* University of St Andrews Module Catalogue
School of Biology Symbiosis Database (module organisers only)
University of St Andrews MMS (St Andrews users only)

Policies

(Information in this section applies to all Biology Modules)