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Metal ions including calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) are essential for human health. Normally the distributions and concentrations of such metals are tightly controlled. If metal ion imbalances occur this leads to a plethora of disease states, including cardiovascular disease and neurological disorders.

The aim of our research is to understand from a molecular to a systems level, the complex mechanisms that regulate metal ion homeostasis and the role that these metal ions play in health and disease.

We use a wide range of experimental approaches, including in vitro functional and biochemical assays and state-of-the-art imaging techniques. Our work is supported by grants from the British Heart Foundation, BBSRC, Tenovus Scotland, Fight for Sight and the Royal Society of Edinburgh.

Dr Alan Stewart

Dr Alan Stewart

Samantha-Pitt_photo

Dr Samantha Pitt